top of page

Non-invasive measurement of retinal blood flow using the XyCAM RI™ retinal imaging system: early cli

ARVO Annual Meeting Abstract | September 2016


Purpose


Quantification of retinal blood flow shows promise as an early biomarker for diverse ocular pathologies such as diabetic retinopathy and glaucoma. We have developed a non-invasive retinal imaging device—the XyCAM RITM—that captures high-resolution fundus images and uses laser speckle contrast imaging (LSCI) to estimate retinal blood flow.


Methods


The right eye of 4 healthy individuals (58-59 years old, 2 male) received tropicamide for pupil dilation and was imaged using the investigational XyCAM RI in a clinical environment. Subjects’ heads were stabilized on a standard clinical chin rest and the XyCAM RI mounted on a slit lamp base for fine motion adjustment (Fig. 1A). Four imaging sessions were conducted on each subject, where each session comprised of an ophthalmologist focusing on a desired region of interest (ROI) in the subject’s retina, followed by rapid, automatic acquisition of 5 red-free fundus photographs (with green illumination) and 120 speckle images (using red laser illumination). For reference, color fundus photographs were also obtained using a Topcon TRC 50DX fundus camera. At least 4 vessel ROIs were identified in each fundus photograph and retinal blood flow velocities (RBFV) were estimated within those ROIs using LSCI-based methods. For each subject, statistical analyses were completed using data from the session with the lowest variation in RBFV estimates.


Full Abstract


Recent News
Check back soon
Once posts are published, you’ll see them here.
bottom of page