Non-invasive measurement of retinal blood flow using the XyCAM RI™ retinal imaging system: early clinical results

September 4, 2016

ARVO Annual Meeting Abstract  |   September 2016

 

Purpose

 

Quantification of retinal blood flow shows promise as an early biomarker for diverse ocular pathologies such as diabetic retinopathy and glaucoma. We have developed a non-invasive retinal imaging device—the XyCAM RITM—that captures high-resolution fundus images and uses laser speckle contrast imaging (LSCI) to estimate retinal blood flow.

 

Methods

 

The right eye of 4 healthy individuals (58-59 years old, 2 male) received tropicamide for pupil dilation and was imaged using the investigational XyCAM RI in a clinical environment. Subjects’ heads were stabilized on a standard clinical chin rest and the XyCAM RI mounted on a slit lamp base for fine motion adjustment (Fig. 1A). Four imaging sessions were conducted on each subject, where each session comprised of an ophthalmologist focusing on a desired region of interest (ROI) in the subject’s retina, followed by rapid, automatic acquisition of 5 red-free fundus photographs (with green illumination) and 120 speckle images (using red laser illumination). For reference, color fundus photographs were also obtained using a Topcon TRC 50DX fundus camera.
At least 4 vessel ROIs were identified in each fundus photograph and retinal blood flow velocities (RBFV) were estimated within those ROIs using LSCI-based methods. For each subject, statistical analyses were completed using data from the session with the lowest variation in RBFV estimates.

 

Full Abstract

Share on Facebook
Share on Twitter
Please reload

Recent News

Vasoptic Medical impresses at ARVO 2017

May 15, 2017

Vasoptic Medical's $1.5 million cash infusion pushes it toward FDA approval

April 25, 2017

Early Detection: New Device Measures Risk of Blindness from Diabetes

October 7, 2016

1/10
Please reload

© 2020 Vasoptic Medical Inc.

1215 E. Fort Ave Suite 304
Baltimore, MD 21230