Clinical Measurement of Retinal Blood Flow using the XyCAM RI™ Handheld Retinal Imager

September 5, 2016

ARVO Annual Meeting Abstract  |   September 2016




The ability to non-invasively acquire quantitative morphological and blood flow measurements in a primary care setting has the potential to enable early and effective diagnoses of debilitating ophthalmic and systemic conditions. Our team has developed a handheld retinal imager—the XyCAM RITM—that can complement fundus images with retinal blood flow (RBF) measurements. Here, we present proof of concept results obtained from clinical investigation of the handheld use of the XyCAM RI.




The handheld XyCAM RI (weight < 1.05kg, length < 30cm) performs fundus photography in green illumination and laser speckle contrast imaging (LSCI) using red laser illumination. During clinical investigation, an ophthalmologist used the handheld XyCAM RI to image the right eye of 4 healthy individuals (58-59 years old, 2 male) through a dilated pupil. No accessories were used for stabilization of the device or the subject’s head. Upon focusing on a retinal region of interest (ROI) that includes the optic nerve head, 5 fundus photographs and 120 speckle images were acquired in rapid succession. Since this use case is susceptible to motion artifact, 4 imaging sessions were conducted and the most reproducible image was considered for analysis. Reference images were obtained using a Topcon TRC 50DX fundus camera. At least 4 vessel ROIs were identified in each image and retinal blood flow velocities (RBFV) were estimated within those ROIs using LSCI-based methods.


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