© 2019 Vasoptic Medical Inc.

1215 E. Fort Ave Suite 304
Baltimore, MD 21230

Optical Imaging of Microvascular Morphology and Perfusion

October 1, 2012

Rege, Abhishek, Nitish V Thakor, and Arvind P Pathak. "Optical imaging of microvascular morphology and perfusion." Current Angiogenesis 1.3 (2012): 243-260.

Optical imaging has emerged as a method of choice for a number of anatomical and physiological studies, especially in animal models. Optical methods offer distinct advantages such as high spatio-temporal resolution, wide array of available contrast moieties (such as fluorescent dyes, microspheres etc.) and the capability of quantitative “functional imaging”. In this review, we focus on techniques that are adept for imaging microvascular morphology and perfusion. Measures of the microvascular architecture include the number, spacing, density and radii of blood vessels. Perfusion indices include the relative and absolute microvascular blood flow and metrics derived from tracer kinetic theory, such as the mean transit time. Following detailed descriptions of the biophysics of different optical imaging approaches, we conclude with a systematic comparison of the strengths and weakness of each depending on the intended application. We believe this review will serve as a useful starting point for anyone interested in the pre-clinical characterization of microvascular morphology and perfusion in health and disease.


Full Article

Share on Facebook
Share on Twitter
Please reload

Recent News

Vasoptic Medical impresses at ARVO 2017

May 30, 2017

Vasoptic Medical's $1.5 million cash infusion pushes it toward FDA approval

April 24, 2017

Title: Ophthalmic examination and disease management with multiple illumination modalities

Patent No. US9492083

Vasoptic receives another patent issuance from The United States Patent and Trademark Office (USPTO)

November 15, 2016

Please reload